Young-sup Yoon et al., Clonally Expanded Novel Multipotent Stem Cells from Human Bone Marrow Regenerate Myocardium after Myocardial Infarction.

• Author: Yoon, Young-Sup
• Position: Abstracts

Young-sup Yoon et al., Clonally Expanded Novel Multipotent Stem Cells from Human Bone Marrow Regenerate Myocardium after Myocardial Infarction, 115 J. CLINICAL INVESTGATION 326 (2005).

Coronary artery disease accounts for 50% of all cardiovascular deaths and nearly 40% of the incidence of heart failure. The current findings have provided evidence that hBMSC transplantation could have relevant implications for the treatment of human disease. The authors have demonstrated here for the first time that adult human stem cells can augment both therapeutic neovascularization and cardiomyogenesis, thereby enhancing functional and anatomic regeneration after myocardial infarction. The new form of cardiac repair may improve the immediate and long-term outcome of ischemic heart disease and may therefore merit clinical investigation in patients with ischemic heart disease.

To summarize, the authors have identified human bone marrow (BM) derived multipotent stern cells that are capable of expansion from a single cell, exhibit unlimited self-renewal, and are capable of triple-lineage differentiation into ECs, smooth muscle cell (SMCs), and cardio-myocyte (CMCs). The transplantation of human BM-derived multipotent stem cells (hBMSCs) into acutely infarcted myocardium attenuates cardiac dysfunction both by de novo differentiation of hBMSCs into myocardial tissues and by paracrine effects, which induced proliferation and preservation of host myocardial cells.

More specifically, the authors have identified a sub-population of stem cells within adult human bone marrow (BM), isolated at the single-cell level, that self-renew without loss of multipotency for more than 140...