Using Human Cell Animal Chimera Brains to Study HIV Latency and Pathology (NIDA)

• Date: 06 August 2020
• DOI: http://doi.org/10.1002/fgc.31231
• Published date: 06 August 2020

Page 8 Federal Grants & Contracts ■ August 6, 2020

© 2020 Wiley Periodicals LLC • All rights reserved • DOI: 10.1002/fgc

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Using Human Cell Animal Chimera Brains

to Study HIV Latency and Pathology (NIDA)

Scope: The National Institute on Drug Abuse seeks

(R01) research project applications for the Using Human

Cell Animal Chimera Brains to Study HIV Latency

and Pathology announcement for preclinical and

translational research using human cell-mice chimera

animals to study HIV pathology in functional live brain

environments, with the presence of abused substances.

Deadline: Letters of Intent, Oct. 13, 2020; proposals,

Nov. 13, 2020.

Funds: $1.5 million in FY2021 for three to four awards.

The maximum project period is ve years.

Eligibility: Colleges and universities; for-prot

organizations, including small businesses; nonprot

organizations; and state, local and Native American

tribal governments; among others.

Areas: NIDA said research areas include but are not

limited to: how HIV-infected microglia alter neural tissue

structure, physiology and function in the HIV-latent, HIV

infected and HIV-free chimeric brain; identifying the

evolving mechanisms of HIV neuropathogenesis in the

chronically combined antiretroviral therapy managed

long-term condition, including the viral genetic or host

epigenetic studies relating to the establishment and

maintenance of viral latency and reservoirs in the

chimeric brain; and synaptodendritic degenerative

changes and neuronal and glial cell losses in the setting

of chronic HIV infection and abused substances, and

effects of those changes when microglia are infected by

HIV, analyzed at the single cell level; among others.

➜ www.grants.gov; FON# RFA-DA-21-026

Promoting Cancer Surveillance Workforce,

Education, and Data Use (CDC)

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Prevention seeks applications for the Promoting

Cancer Surveillance Workforce, Education, and Data

Use announcement to build upon the success of the

National Program of Cancer Registries (NPCR) by

expanding opportunities to enhance registrars’ capacity

and resources to support recruitment and retention and

promote cancer surveillance data.

Deadline: Nov. 24, 2020.

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Eligibility: Unrestricted.

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1605 and the successes and lessons learned from that

project. The strengthening of the cancer surveillance

workforce in this project will bolster NPCR registries’

capacity to comply with Public Law 102–515, the Cancer

Registries Amendment Act, which requires the complete,

timely and accurate reporting of all malignancies and

benign central nervous system tumors.

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