Position:Clinical report

Synexus has collaborated with the University of Exeter in the United Kingdom to launch one of the largest, registry- based research initiatives in the United States to help understand how healthy brains age.

The initial goal of the Synexus HealthyMinds Registry (Synexus HMR) is to register 30,000 adults age 50 or older without signs of dementia for a five-year study to examine the lifestyle and genetic risk factors impacting cognitive function over time to identify potential methods of prevention and possible treatments.

Synexus is collaborating with Acurian, a leading full- service provider of global patient enrollment and retention solutions, to help enroll study participants. Synexus and Acurian are part of Accelerated Enrollment Solutions (AES), a business unit of Pharmaceutical Product Development, LLC (PPD), the global contract research organization. Drawing on its extensive recruitment expertise and a database of over 100 million U.S. households, Acurian provides one of the largest pools of potential participants for Alzheimer's disease longitudinal screening.

Synexus HMR offers participants the opportunity to help society, and potentially themselves and their loved ones, better understand what causes cognitive decline, said Dawie Wessels, chief medical officer of Synexus. We hope to identify ways to prevent and treat dementia so people can maintain greater independence as they age. The registry provides a high level of engagement, pushing out relevant information about the latest advancements in dementia research and treatments, as well as brain-training games designed to help participants stay sharp.

The first Synexus HMR study is being conducted exclusively online, meaning people with access to the internet can participate in cognitive assessments, lifestyle and medical questionnaires, and brain-training exercises without leaving their homes. In addition, participants will be among the first to learn about clinical trials of promising new treatments for Alzheimer's and other forms of dementia. Additional information about Synexus HMR and how to participate at no cost is available at

We know dementia risk can be reduced by one-third through improving lifestyle factors from midlife, said Professor Clive Ballard, executive dean and pro-vice-chancellor of the University of Exeter Medical School. Our study in the United States will provide valuable information about how the brain changes with age, which combination...

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