Gene reprogramming has become possible.

Position:Stem Cells - Brief article

Gene therapy has moved one step closer to clinical reality as scientists from the Morganridge Institute for Research at the University of Wisconsin, Madison, have determined that the process of correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells (IPSCs), suggesting they may be cultured into subsequent generations of cells that remain free of the initial disease. However, although gene correction itself does not increase the instability or number of observed mutations in the cells, the study reinforced other recent findings that IPSCs themselves carry a significant number of genetic mutations.

"This study shows that the process of gene correction is compatible with therapeutic use," says Sara Howden, primary author of the study, and a postdoctoral research associate. "It also was the first to demonstrate that correction of a defective gene in patient-derived cells via homologous recombination is possible."

Like human embryonic stem cells, IPSCs...

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