Hot flash, cold cash: how a once-respected women's group went through the change--with the help of drug industry money.

• Author: Mundy, Alicia

LAST APRIL, SEVERAL HUNDRED BLACK-TIE and couture-clad worthies crowded into the ornate ballroom of the Washington Ritz-Carlton for one more dinner on the spring charity circuit. This one seemed especially well-suited for the usual crowd of congressmen's wives and old-school hostesses. Themed "Coming of Age," the entire evening was a salute to the vibrancy of middle-aged women--from the appearance by Cheryl Ladd of "Charlie's Angels" fame, glittering and trim at 51; through a special photography exhibit tided "A Celebration of Women in Midlife and Beyond"; to a performance by 38-year-old country singer Trisha Yearwood.

Ostensibly, "Coming of Age" was thrown for the benefit of a group that enjoys, or enjoyed, a sterling reputation and pursued an unexceptionable purpose: the Society for Women's Health Research, a 12-year-old Beltway nonprofit whose "sole mission is to improve the health of women through research," according to its brochure. But there was something different about this evening's charity ball. The whole event had been underwritten by the pharmaceutical company Wyeth, which also happens to manufacture Prempro, the drug most widely used in hormone-replacement therapy (HRT) for post-menopausal women. That evening, after a brief speech by Wyeth's CEO Robert Essner, the celebrities joined menopause maven Gail Sheehy to. read literary selections celebrating what the society called "advances in the quality and duration of a woman's life." Sheehy read from her own book The Silent Passage, noting how women were enjoying better lives because of "lifesaving preventative measures" including "hormone-replacement therapy."

Some participants were taken aback. "Without mentioning Wyeth," says one, "It was like they were doing an ad for Wyeth." The whole evening was, she recalls, "a perfect way to ensure you'll keep one of your biggest benefactors happy: a dinner theme tied to one of their biggest selling products." A week later, Wyeth presented the society with a $250,000 check at a special event celebrating the 60th anniversary of Premarin, the company's other HRT drug.

All nonprofits, of course, must occasionally confront the tension between what's good for their stated mission and what's good for their funders. But the Society for Women's Health Research has clearly decided to bend to the latter. For decades, middle-aged women in America had been encouraged to take medications to replace the estrogen which the body ceases to produce adequately after menopause; last year, doctors wrote a total of 67 million prescriptions for such drugs, including 22 million for Prempro (which contains estrogen compounded with progestin). The medications were once considered post-menopausal wonder drugs--relieving hot flashes and insomnia, preserving mental acuity and bone strength, and, most importantly, staving off heart disease.

But as researchers examined the drugs more closely in the 1990s, they began to have second thoughts. Women on such drugs as Prempro were suffering fewer bone fractures and developing illnesses like colon cancer less often, but they were showing an increased susceptibility to strokes and blood clots. Indeed, during the two years before the society's gala, women taking Prempro had received two well-publicized letters from the directors of a major National Institutes of Health study of HRT warning them of possible heart problems connected to the drug. Months before the gala, several respected medical journals published studies suggesting links between breast cancer and the use of some types of estrogen.

These problems were to some extent well known within the women's health community the night of the gala. But the biggest bombshell burst three months later, when NIH officials halted the HRT study, and concluded, five years into the planned eight-year trial, that the verdict was clear: Although Prempro did some good when taken for shorter periods of time (i.e. during menopause), long-term use of the drug--as advocated by its makers--significantly increased the risk of heart attacks, stroke, blood clots, and last, but not least, breast cancer. Sales of...