Caisson Biotech has been issued a new patent, U.S. patent 9,370,583, by the U.S. Patent and Trademark Office for long lasting recombinant heparosan Factor VIIa conjugate. The naturally occurring polysaccharide, heparosan, has proven to be as effective as polyethylene glycol (PEG) in prolonging the half-life of haemophilia FVIIa, but retains significantly higher activity (48 [+ or -] 4)%, as compared to (27 [+ or -] 1)% for a corresponding PEG conjugate. Results were presented at the recent World Federation of Hemophilia World Congress Conference.

While recombinant FVIIa is a safe and reliable option for treatment of bleeding episodes in haemophilia patients with inhibitors, a longer acting molecule is desirable for routine prophylaxis. PEG conjugation is effective in prolonging the in vivo half-life of FVIIa, however, at the expense of a significant reduction in activity. Caisson Biotech's HEPtune is a new half-life extension principle based on the conjugation of a naturally occurring heparosan polysaccharide coupled to active pharmaceutical ingredients, providing enhancement of therapeutics. Heparosan can be produced chemoenzymatically, which allows for tailoring of size and incorporation of chemical handles for drug conjugation. The heparosan conjugation technology offers a novel approach to existing industry half-life extension technologies including PEGylation, Fc fusion to immunoglobulin, and Fc fusion to albumin.

Novo Nordisk entered into an exclusive license with Caisson in 2012 for haemophilia drug targets, which was later expanded in 2014. Novo Nordisk, as a world leader in protein therapeutics, has been a strong foundational partner for Caisson. The partnership has helped identify strengths with our technology and has further validated...

To continue reading