Bottoms up means bottoming out.

PositionWomen's Health - Researchers find that health risks posed by alcoholism are worse for women than men - Brief Article

Drinking alcohol may pose more health risks for women than men. Because females generally are smaller and have a higher percentage of body fat than males, they metabolize alcohol less efficiently. Researchers, however, have found the effects of alcohol on women go far beyond size and metabolism. Mayo Clinic Women's HealthSource outlines several areas where women appear to be more prone to alcohol-related health conditions.

Liver damage: Women develop alcohol-induced liver diseases over a shorter time and after consuming less alcohol. Findings suggest females are more likely to contract alcoholic hepatitis and to die of cirrhosis of the liver.

Brain damage: Women may be more vulnerable to alcohol-induced brain damage. The region involved in coordinating multiple brain functions is significantly smaller among alcoholic women than among nonalcoholic females or alcoholic males.

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